Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23520743 | 0.86 | PARP1 (0.70) | PARP1TYMSRAB9AMAPTKDM4E | |
| SCHEMBL31537876 | 0.83 | PARP1 (0.58) | PARP1TYMSRAB9AMAPTKDM4E | |
| SCHEMBL27167458 | 0.81 | PARP1 (0.50) | PARP1TYMSRAB9AMAPTKDM4E | |
| SCHEMBL30056850 | 0.81 | PARP1 (0.50) | PARP1TYMSRAB9AMAPTKDM4E | |
| SCHEMBL6979552 | 0.79 | PPARG (0.46) | PARP1EGFRRAB9AMAPTMEN1 | |
| SCHEMBL24104840 | 0.77 | PARP1 (0.53) | PARP1TYMSRAB9AMAPTKDM4E | |
| SCHEMBL30900892 | 0.76 | PARP1 (0.70) | PARP1TYMSRAB9AMAPTKDM4E | |
| SCHEMBL6931033 | 0.76 | PARP1 (0.70) | PARP1TYMSRAB9AMAPTKDM4E | |
| SCHEMBL30289793 | 0.75 | MAPT (0.55) | PARP1EGFRRAB9AMAPTKDM4E | |
| SCHEMBL23412966 | 0.74 | PARP1 (0.54) | PARP1TYMSRAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951029-B2 | Styryl quinazoline derivatives as pharmaceutically active agents | VICHEM CHEMIE KUTATÓ KFT. (HU) | 2018-04-24 | — | — | US | disclosed |
| US-20160194291-A1 | STYRYL QUINAZOLINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE AGENTS | VICHEM CHEMIE KUTATÓ KFT. (HU) | 2016-07-07 | — | — | US | disclosed |
| US-8183276-B2 | Therapeutic agents | MERCK SHARP & DOHME CORP. | 2012-05-22 | — | — | US | disclosed |
| US-20100324029-A1 | THERAPEUTIC AGENTS | MERCK SHARP & DOHME CORP. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324029-A1 | THERAPEUTIC AGENTS | PSEN2, PSEN1, BACE2 | PARP1 1371/4885EGFR 3171/4885TYMS 1399/4885 |
| US-20160194291-A1 | STYRYL QUINAZOLINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE AGENTS | FLT3, BCR, STK3 | PARP1 1606/4885EGFR 243/4885TYMS 231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.