Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.78 |
| ▸ | PRKCB | P05771 | 13/20 | 0.78 |
| ▸ | PRKCA | P17252 | 13/20 | 0.78 |
| ▸ | PRKCG | P05129 | 12/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.78 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.78 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.78 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.55 |
| ▸ | IDH1 | O75874 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3779590 | 0.97 | GSK3B (0.79) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5756894 | 0.94 | GSK3B (0.76) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL4337272 | 0.92 | GSK3B (0.72) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL3780370 | 0.90 | GSK3B (0.79) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL4337262 | 0.89 | GSK3B (0.83) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL1127953 | 0.89 | GSK3B (0.68) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL5757323 | 0.89 | GSK3B (0.70) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL3780405 | 0.88 | GSK3B (0.79) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL13013272 | 0.88 | GSK3B (1.00) | GSK3BPRKCBPRKCAPRKCGKCNH2 | |
| SCHEMBL13013365 | 0.88 | GSK3B (0.73) | GSK3BPRKCBPRKCAPRKCGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-A2 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002046183-A2 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-06-13 | — | — | WO | disclosed |