Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | HRH2 | P25021 | 8/20 | 0.38 |
| ▸ | HRH1 | P35367 | 8/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6740792 | 0.87 | SLC6A4 (0.41) | HRH3SLC6A4HRH2HRH1CACNA1F | |
| SCHEMBL6977224 | 0.84 | HRH3 (0.40) | HRH3SLC6A4GRIN1GRIN2BHRH2 | |
| SCHEMBL6620971 | 0.82 | HRH1 (0.41) | HRH3GRIN1GRIN2BHRH2HRH1 | |
| SCHEMBL6978560 | 0.81 | HRH1 (0.38) | HRH3SLC6A4GRIN1GRIN2BHRH2 | |
| SCHEMBL6621387 | 0.80 | HRH1 (0.37) | HRH3SLC6A4HRH2HRH1CACNA1F | |
| SCHEMBL6093345 | 0.77 | HRH3 (0.42) | HRH3SLC6A4HRH2HRH1CACNA1F | |
| SCHEMBL6992027 | 0.77 | HRH3 (0.39) | HRH3SLC6A4HRH2HRH1ADRA1D | |
| SCHEMBL7250863 | 0.76 | HRH3 (0.46) | HRH3SLC6A4GRIN1GRIN2BHRH2 | |
| SCHEMBL6739004 | 0.76 | POLB (0.40) | HRH3SLC6A4HRH2HRH1DRD3 | |
| SCHEMBL6733555 | 0.76 | PDE4B (0.39) | HRH3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192155-B1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| US-6465481-B1 | EXHIBIT ELECTROPHYSIOLOGICAL ACTIVITY; MAY BE MORE POTENT AND PRODUCE FEWER SIDE EFFECTS INCLUDING LOWER INCIDENCE OF PROARRHYTHMIAS SUCH AS TORSADES DE POINTES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | disclosed |