SCHEMBL6984546

SCHEMBL6984546

CC(=O)Nc1nc(-c2cc(Cl)nc(Cl)c2)cs1

nearest known ligand 0.69

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 9/20 0.69
RAB9A P51151 5/20 0.60
NPC1 O15118 5/20 0.60
HSD17B10 Q99714 3/20 0.58
KMT2A Q03164 3/20 0.58
ALDH1A1 P00352 2/20 0.58
MAPK1 P28482 2/20 0.58
MEN1 O00255 2/20 0.58
ALOX15 P16050 1/20 0.58
SMN1; SMN2 Q16637 3/20 0.56
HPGD P15428 1/20 0.56
HTT P42858 1/20 0.56
TYR P14679 1/20 0.55
KDM4E B2RXH2 2/20 0.54
LMNA P02545 1/20 0.52
POLB P06746 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9893009 0.82 ABL1 (1.00) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL25735740 0.81 ABL1 (1.00) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL29419362 0.80 ABL1 (1.00) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL18387706 0.80 ABL1 (1.00) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL17400591 0.79 ABL1 (0.62) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL17412735 0.79 ABL1 (0.62) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL1938172 0.79 SMN1; SMN2 (0.62) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL10699534 0.78 ABL1 (0.73) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL2020280 0.78 ABL1 (0.73) ABL1RAB9ANPC1HSD17B10KMT2A
SCHEMBL17400630 0.78 ABL1 (0.68) ABL1RAB9ANPC1HSD17B10KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828738-B1 PYRIDYL-THIAZOLES AND THEIR USE TO PROTECT PLANTS AGAINST INFECTIONS BY MICRO-ORGANISMS BAYER CROPSCIENCE AG (DE) 2003-12-17 EP disclosed
CN-1295066-A Malonate derivative, its prep. and use BAYER AG (DE) 2001-05-16 CN disclosed
CN-1065242-C Pyridyl-thiazoles BAYER AG (DE) 2001-05-02 CN disclosed
US-6160121-A Pyridyl-thiazoles and their use to protect plants against infections by micro-organisms BAYER AKTIENGESELLSCHAFT (DE) 2000-12-12 US disclosed
US-6136754-A DIALKYL 2,6-DICHLOROISONICOTINOYLMALONATES BAYER AKTIENGESELLSCHAFT (DE) 2000-10-24 US disclosed
CN-1190969-A Pyridyl-thiazoles BAYER AG (DE) 1998-08-19 CN disclosed
EP-0828738-A1 PYRIDYL-THIAZOLES AND THEIR USE TO PROTECT PLANTS AGAINST INFECTIONS BY MICRO-ORGANISMS BAYER AG (DE) 1998-03-18 EP disclosed
WO-1996037493-A1 PYRIDYL-THIAZOLES AND THEIR USE TO PROTECT PLANTS AGAINST INFECTIONS BY MICRO-ORGANISMS BAYER AKTIENGESELLSCHAFT (DE) 1996-11-28 WO disclosed