Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | PDE4A | P27815 | 7/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.49 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977325 | 0.79 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL12464179 | 0.79 | PDE4B (0.61) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL683182 | 0.78 | PDE4B (0.56) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL8274275 | 0.78 | PDE4B (0.56) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL6985006 | 0.77 | PDE4B (0.53) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL3119101 | 0.76 | PDE4B (0.63) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL2671425 | 0.76 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL12396247 | 0.75 | PDE4B (0.54) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL20869165 | 0.75 | PDE4B (0.53) | PDE4BPDE3APDE4APDE4CPDE4D | |
| SCHEMBL2131813 | 0.75 | PDE4B (0.39) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946541-B1 | QUINOLINES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-07-30 | — | — | EP | disclosed |
| US-6069151-A | Quinolines and their therapeutic use | DARWIN DISCOVERY, LTD. (GB) | 2000-05-30 | — | — | US | disclosed |
| EP-0946541-A1 | QUINOLINES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998020007-A1 | QUINOLINES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1998-05-14 | — | — | WO | disclosed |