Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 19/20 | 0.66 |
| ▸ | BCL2 | P10415 | 14/20 | 0.66 |
| ▸ | BCL2L2 | Q92843 | 6/20 | 0.66 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4467877 | 1.00 | BCL2L1 (0.66) | BCL2L1BCL2BCL2L2MCL1AURKA | |
| SCHEMBL2947902 | 0.88 | BCL2L1 (0.53) | BCL2L1BCL2BCL2L2MCL1 | |
| SCHEMBL2946923 | 0.84 | BCL2L1 (0.78) | BCL2L1BCL2BCL2L2MCL1AURKA | |
| SCHEMBL2946925 | 0.84 | BCL2L1 (0.78) | BCL2L1BCL2BCL2L2MCL1AURKA | |
| SCHEMBL2948598 | 0.84 | BCL2L1 (0.76) | BCL2L1BCL2BCL2L2MCL1AURKA | |
| SCHEMBL2945334 | 0.84 | BCL2L1 (0.75) | BCL2L1BCL2BCL2L2MCL1AURKA | |
| SCHEMBL2949773 | 0.83 | BCL2L1 (0.78) | BCL2L1BCL2BCL2L2MCL1AURKA | |
| SCHEMBL2943765 | 0.83 | BCL2L1 (0.78) | BCL2L1BCL2BCL2L2MCL1AURKA | |
| SCHEMBL2951125 | 0.83 | BCL2L1 (0.69) | BCL2L1BCL2BCL2L2MCL1AURKA | |
| SCHEMBL2944554 | 0.83 | BCL2L1 (0.78) | BCL2L1BCL2BCL2L2MCL1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318978-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024636-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2002-03-28 | — | — | WO | disclosed |