Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 2/20 | 0.51 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984824 | 0.94 | F10 (0.50) | C1SF10F2HTR1ADRD4 | |
| SCHEMBL6979340 | 0.94 | F10 (0.48) | C1SF10F2HTR1ADRD4 | |
| SCHEMBL6982988 | 0.93 | F10 (0.47) | C1SF10F2HTR1ADRD4 | |
| SCHEMBL6979284 | 0.92 | C1S (0.45) | C1SF10F2HTR1ADRD4 | |
| SCHEMBL6969289 | 0.92 | F10 (0.47) | C1SF10F2HTR1ADRD4 | |
| SCHEMBL6982312 | 0.92 | F10 (0.47) | C1SF10F2HTR1ADRD4 | |
| SCHEMBL6979107 | 0.92 | F10 (0.56) | C1SF10F2HTR1ADRD4 | |
| SCHEMBL6980328 | 0.91 | F10 (0.45) | C1SF10F2KMT2AALDH1A1 | |
| SCHEMBL6982494 | 0.90 | C1S (0.41) | C1SF10F2KMT2AALDH1A1 | |
| SCHEMBL6983358 | 0.90 | POLB (0.43) | C1SF10F2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012166-B1 | 1-AMINO-7-ISOQUINOLINE DERIVATIVES AS SERINE PROTEASE INHIBITORS | TULARIK LTD (GB) | 2003-10-29 | — | — | EP | disclosed |
| US-6420438-B1 | FOR THERAPY OF THROMBOTIC DISEASE, ASTHMA, EMPHYSEMA, CIRRHOSIS, ARTHRITIS, CARCINOMA, MELANOMA, RESTENOIS, ATHEROMA, TRAUMA, SHOCK AND REPERFUSION INJURY | TULARIK LIMITED (GB) | 2002-07-16 | — | — | US | disclosed |
| US-6262069-B1 | 1-amino-7-isoquinoline derivatives as serine protease inhibitors | PROTHERICS MOLECULAR DESIGN LIMITED (GB) | 2001-07-17 | — | — | US | disclosed |