Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 10/20 | 0.45 |
| ▸ | KIF5B | P33176 | 6/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981093 | 0.95 | EGFR (0.47) | EGFRRETKIF5BAURKBAURKA | |
| SCHEMBL5827881 | 0.94 | RET (0.47) | EGFRRETKIF5BAURKBKDR | |
| SCHEMBL5827885 | 0.94 | RET (0.47) | EGFRRETKIF5BAURKBKDR | |
| SCHEMBL5828868 | 0.88 | HTT (0.48) | EGFRRETKIF5BKDRALDH1A1 | |
| SCHEMBL5828872 | 0.88 | HTT (0.48) | EGFRRETKIF5BKDRALDH1A1 | |
| SCHEMBL5828851 | 0.88 | KDM1A (0.49) | EGFRRETKIF5BAURKBAURKA | |
| SCHEMBL5828850 | 0.88 | KDM1A (0.49) | EGFRRETKIF5BAURKBAURKA | |
| SCHEMBL5828583 | 0.84 | RET (0.41) | EGFRRETKIF5BAURKBAURKA | |
| SCHEMBL5828593 | 0.84 | RET (0.41) | EGFRRETKIF5BAURKBAURKA | |
| SCHEMBL5828728 | 0.82 | EGFR (0.50) | EGFRRETAURKBAURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |