Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 11/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982306 | 0.91 | IDH1 (0.41) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6982542 | 0.86 | IDH1 (0.47) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6982179 | 0.78 | IDH1 (0.47) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6986966 | 0.76 | IDH1 (0.51) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6981895 | 0.75 | LCK (0.53) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27581646 | 0.75 | LCK (0.53) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6983920 | 0.75 | MAPK14 (0.50) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6981916 | 0.75 | MAPK14 (0.45) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6987088 | 0.74 | LCK (0.53) | IDH1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL27581621 | 0.74 | LCK (0.53) | IDH1MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224180-B1 | SUBSTITUTED AZOLES | NOVARTIS AG (CH) | 2003-07-02 | — | — | EP | claimed |