Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 9/20 | 0.49 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423200 | 0.88 | KDM4E (0.49) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL5421604 | 0.84 | KDM4E (0.46) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL5415087 | 0.82 | KDM4E (0.55) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL5419802 | 0.81 | KDM4E (0.54) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL5427194 | 0.81 | SMN1; SMN2 (0.50) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL5419706 | 0.80 | KDM4E (0.52) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL5418844 | 0.80 | KDM4E (0.52) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL14416785 | 0.79 | KDM4E (0.51) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL5415100 | 0.77 | DYRK1A (0.52) | KDM4ESMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL14409229 | 0.77 | APP (0.51) | KDM4ESMN1; SMN2NPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345914-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051821-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-04 | — | — | WO | disclosed |