Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995581 | 0.90 | HRH1 (0.57) | HRH1HTR2AHTR1ADRD2 | |
| SCHEMBL6989903 | 0.87 | HRH1 (0.45) | HRH1EPHX2KCNH2HTR2ASMN1; SMN2 | |
| SCHEMBL6991699 | 0.81 | HRH1 (0.68) | HRH1HTR2AHTR1ADRD2 | |
| Water SCHEMBL6994538 | 0.78 | HRH1 (0.62) | HRH1HTR2ASMN1; SMN2MAPK1HTR2B | |
| SCHEMBL6990349 | 0.77 | HRH1 (0.68) | HRH1HTR2AHTR1ADRD2 | |
| Water SCHEMBL6988769 | 0.76 | HRH1 (0.59) | HRH1MEN1CYP2D6CYP2C9KMT2A | |
| Water SCHEMBL9129109 | 0.75 | HRH1 (0.38) | HRH1KCNH2HTR2AMAPTHTR1A | |
| Water SCHEMBL6988465 | 0.75 | HRH1 (0.38) | HRH1KCNH2HTR2AMAPTHTR1A | |
| Water SCHEMBL9383772 | 0.74 | HRH1 (0.57) | HRH1MEN1KMT2ANPSR1POLB | |
| SCHEMBL6999312 | 0.74 | HRH1 (0.61) | HRH1HRH3CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588859-B1 | Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA NV (BE) | 2003-08-13 | — | — | EP | disclosed |
| US-5461050-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-24 | — | — | US | disclosed |
| EP-0518434-A1 | Imidazo(1,2-a)(pyrrolo, thieno or furano)(3,2-d)azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |