Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 20/20 | 0.57 |
| ▸ | PPARA | Q07869 | 13/20 | 0.57 |
| ▸ | PPARG | P37231 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4808025 | 0.93 | PPARD (0.65) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4809754 | 0.89 | PPARD (0.59) | PPARDPPARAPPARG | |
| SCHEMBL4801366 | 0.88 | PPARD (0.56) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4801990 | 0.88 | PPARD (0.56) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4803214 | 0.88 | PPARD (0.56) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4809367 | 0.87 | PPARD (0.68) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4807084 | 0.87 | PPARD (0.46) | PPARDPPARAPPARGMAPT | |
| SCHEMBL4801192 | 0.87 | PPARD (0.63) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4809791 | 0.86 | PPARD (0.69) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4808683 | 0.86 | PPARD (0.51) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349843-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | GLAXO GROUP LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002059098-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | GLAXO GROUP LIMITED (GB) | 2002-08-01 | — | — | WO | disclosed |