Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668884 | 0.93 | F2 (0.59) | F2LMNARAB9AKDM4EHSD17B10 | |
| SCHEMBL6986197 | 0.86 | F2 (0.56) | F2ALDH1A1 | |
| SCHEMBL6974717 | 0.86 | F2 (0.62) | F2LMNASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL6986249 | 0.85 | F2 (0.61) | F2LMNASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL6983784 | 0.84 | F2 (0.48) | F2LMNARAB9AKDM4EHSD17B10 | |
| SCHEMBL6986674 | 0.84 | F2 (0.61) | F2F10F7 | |
| SCHEMBL7396594 | 0.82 | F2 (0.58) | F2MMP13 | |
| SCHEMBL6985965 | 0.82 | F2 (0.57) | F2ALDH1A1F10 | |
| SCHEMBL7670676 | 0.79 | F2 (0.69) | F2LMNA | |
| Hydrochloric Acid SCHEMBL6964830 | 0.79 | F2 (0.51) | F2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220844-B1 | ARYL SULFONAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES THEREOF AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-04-09 | — | — | EP | disclosed |
| US-6365584-B1 | FOR PROPHYLAXIS AND THERAPY OF INFLAMMATORY AND/OR ALLERGIC DISEASES, LUNG FIBROSIS, FIBROSING ALVEOLITIS AND SCARRING, COLLAGENOSES SUCH AS LUPUS ERYTHEMATODES AND SCLERODERMIA AS WELL AS ARTERIOSCLEROSIS, PSORIASIS AND NEOPLASM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-04-02 | — | — | US | disclosed |