Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7523189 | 0.90 | KMT2A (0.56) | KDM4EPOLBMEN1KMT2AGAA | |
| SCHEMBL8531035 | 0.90 | GAA (0.58) | KDM4EPOLBMEN1KMT2AGAA | |
| SCHEMBL8026568 | 0.86 | GAA (0.55) | KDM4EPOLBMEN1KMT2AGAA | |
| SCHEMBL207179 | 0.86 | GAA (0.62) | KDM4EPOLBMEN1KMT2AGAA | |
| SCHEMBL11922794 | 0.85 | KMT2A (0.60) | KDM4EPOLBMEN1KMT2AGAA | |
| Hydrochloric Acid SCHEMBL8410665 | 0.84 | GAA (0.65) | KDM4EPOLBMEN1KMT2AGAA | |
| SCHEMBL8533124 | 0.84 | GAA (0.60) | KDM4EPOLBMEN1KMT2AGAA | |
| SCHEMBL8026574 | 0.84 | GAA (0.60) | KDM4EPOLBMEN1KMT2AGAA | |
| SCHEMBL6929324 | 0.84 | GAA (0.60) | KDM4EPOLBMEN1KMT2AGAA | |
| Acetic Acid SCHEMBL8322779 | 0.84 | MEN1 (0.62) | KDM4EPOLBMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733632-B1 | Cyclic compounds, their production and use as tachykinin receptor antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-06-04 | — | — | EP | disclosed |
| US-6147071-A | TACHYKININ RECEPTOR ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5786352-A | CARDIOVASCULAR DISORDERS, TACHYKININ RECEPTOR ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-07-28 | — | — | US | disclosed |
| US-5770590-A | EXCELLENT TACHYKININ RECEPTOR ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-23 | — | — | US | disclosed |
| CN-1140172-A | Cyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-01-15 | — | — | CN | disclosed |
| EP-0733632-A1 | Cyclic compounds, their production and use as tachykinin receptor antagonists | Takeda Chemical Industries, Ltd. (JP) | 1996-09-25 | — | — | EP | disclosed |