Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986843 | 0.83 | KMT2A (0.50) | SMN1; SMN2HTTLMNATSHRKMT2A | |
| SCHEMBL6989125 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1HTTGALR3LMNA | |
| SCHEMBL6992720 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1HTTGALR3LMNA | |
| SCHEMBL6992717 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1HTTGALR3LMNA | |
| SCHEMBL6988643 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPK1HTTGALR3LMNA | |
| SCHEMBL1163936 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPK1HTTGALR3LMNA | |
| SCHEMBL6987777 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPK1HTTGALR3LMNA | |
| SCHEMBL19334487 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1HTTGALR3LMNA | |
| SCHEMBL6323420 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1HTTGALR3LMNA | |
| SCHEMBL6989653 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPK1HTTGALR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | claimed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | claimed |