Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 20/20 | 0.64 |
| ▸ | ESR1 | P03372 | 14/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5436427 | 0.88 | ESR2 (0.80) | ESR2ESR1HDAC6 | |
| SCHEMBL3930187 | 0.79 | ESR2 (1.00) | ESR2ESR1HDAC6 | |
| SCHEMBL29820049 | 0.77 | ESR2 (0.50) | ESR2ESR1HDAC6 | |
| SCHEMBL29819585 | 0.77 | ESR2 (0.50) | ESR2ESR1HDAC6 | |
| SCHEMBL13865476 | 0.74 | NPC1 (0.56) | ESR2ESR1HDAC6 | |
| SCHEMBL26390969 | 0.74 | SMN1; SMN2 (0.56) | ESR2ESR1HDAC6 | |
| SCHEMBL14409224 | 0.74 | ESR2 (0.74) | ESR2ESR1HDAC6 | |
| SCHEMBL5417126 | 0.72 | ESR1 (0.51) | ESR2ESR1HDAC6 | |
| SCHEMBL14409193 | 0.72 | ESR2 (0.72) | ESR2ESR1HDAC6 | |
| SCHEMBL5421050 | 0.72 | ESR2 (0.72) | ESR2ESR1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345914-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051821-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-04 | — | — | WO | disclosed |