Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | DHODH | Q02127 | 10/20 | 0.50 |
| ▸ | PARP1 | P09874 | 7/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972586 | 0.78 | HPSE (0.46) | KDM4EHPGDMAOBADORA2A | |
| Hydrochloric Acid SCHEMBL11789101 | 0.77 | HPSE (0.45) | KDM4EHPGDMAOBADORA2A | |
| Hydrochloric Acid SCHEMBL11786682 | 0.77 | HPSE (0.45) | KDM4EHPGDMAOBADORA2A | |
| SCHEMBL4239910 | 0.77 | MAOB (0.47) | DHODHPARP1MAOBADORA2AADORA2B | |
| SCHEMBL4244245 | 0.76 | MAOB (0.65) | KDM4EHPGDDHODHPARP1MAOB | |
| SCHEMBL4243664 | 0.76 | DHODH (0.62) | KDM4EHPGDDHODHPARP1MAOB | |
| SCHEMBL11020624 | 0.76 | PKN1 (0.49) | PARP1MAOBADORA2AADORA2BADORA1 | |
| SCHEMBL4241721 | 0.76 | NPC1 (0.58) | KDM4EHPGDMAOBADORA2AADORA2B | |
| SCHEMBL4244787 | 0.76 | MAOB (0.51) | KDM4EHPGDDHODHPARP1MAOB | |
| SCHEMBL27720114 | 0.75 | KDM4E (0.57) | KDM4EHPGDDHODHPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920314-B1 | NON-PEPTIDE G-CSF MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-08-27 | — | — | EP | disclosed |
| EP-0920314-A4 | NON-PEPTIDE G-CSF MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2001-08-16 | — | — | EP | disclosed |
| US-5981551-A | GRANULOCYTE COLONY-STIMULATING FACTOR MIMETICS; TREATMENT OF NEUTROPENIA | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0920314-A1 | NON-PEPTIDE G-CSF MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1997044033-A1 | NON-PEPTIDE G-CSF MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-27 | — | — | WO | disclosed |