Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 13/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | BRD2 | P25440 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6750851 | 1.00 | BRD4 (0.49) | BRD4ALDH1A1BRD2LMNAMEN1 | |
| SCHEMBL5424347 | 1.00 | BRD4 (0.49) | BRD4ALDH1A1BRD2LMNAMEN1 | |
| SCHEMBL6750882 | 0.88 | BRD4 (0.55) | BRD4ALDH1A1BRD2MEN1KMT2A | |
| SCHEMBL6989942 | 0.88 | BRD4 (0.55) | BRD4ALDH1A1BRD2MEN1KMT2A | |
| SCHEMBL6750881 | 0.88 | BRD4 (0.55) | BRD4ALDH1A1BRD2MEN1KMT2A | |
| SCHEMBL5425691 | 0.88 | BRD4 (0.51) | BRD4BRD2MEN1KMT2AAURKA | |
| SCHEMBL5171625 | 0.88 | BRD4 (0.51) | BRD4BRD2MEN1KMT2AAURKA | |
| SCHEMBL5171632 | 0.88 | BRD4 (0.51) | BRD4BRD2MEN1KMT2AAURKA | |
| SCHEMBL5624756 | 0.87 | BRD4 (0.46) | BRD4BRD2MEN1KMT2AAURKA | |
| SCHEMBL5624761 | 0.87 | BRD4 (0.46) | BRD4BRD2MEN1KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341760-A1 | SULFONYLAMINO SUBSTITUTED 3-(AMINOMETHYLIDE)-2-INDOLINONES AS CELL PROLIFERATION INHIBITORS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2003-09-10 | — | — | EP | claimed |
| WO-2002036564-A1 | SULFONYLAMINO SUBSTITUTED 3-(AMINOMETHYLIDE)-2-INDOLINONES AS CELL PROLIFERATION INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-05-10 | — | — | WO | claimed |