Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394742 | 0.93 | CASR (0.53) | CASRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL4401811 | 0.90 | CASR (0.42) | CASREPHX2HTTSMN1; SMN2 | |
| SCHEMBL4394368 | 0.89 | CASR (0.50) | CASRNPC1RAB9AMEN1KMT2A | |
| SCHEMBL4399190 | 0.86 | CASR (0.41) | CASREPHX2SMN1; SMN2 | |
| SCHEMBL4394783 | 0.86 | CASR (0.42) | CASREPHX2MEN1KMT2AHTR2C | |
| SCHEMBL4392185 | 0.85 | KCNA5 (0.42) | CASRNPC1RAB9AKMT2AHTR2C | |
| SCHEMBL14472757 | 0.84 | CASR (0.35) | CASRNPC1RAB9AEPHX2MEN1 | |
| SCHEMBL4394724 | 0.84 | HTR2C (0.38) | CASRNPC1RAB9AEPHX2MEN1 | |
| SCHEMBL4398149 | 0.83 | EPHX2 (0.38) | CASREPHX2MEN1KMT2AHTR2C | |
| SCHEMBL4399460 | 0.81 | KCNA5 (0.43) | NPC1RAB9AKMT2AHTR2CHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358171-A2 | NOVEL UREA DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | Aventis Pharma S.A. (FR) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002059102-A2 | UREA DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND USE | AVENTIS PHARMA S.A. (FR) | 2002-08-01 | — | — | WO | disclosed |