Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28798183 | 0.81 | EPHX2 (0.31) | — | |
| SCHEMBL6080514 | 0.74 | SMN1; SMN2 (0.31) | GNAI3GNAO1GNAI1 | |
| SCHEMBL22126575 | 0.74 | SMN1; SMN2 (0.31) | GNAI3GNAO1GNAI1 | |
| SCHEMBL5745658 | 0.74 | SMN1; SMN2 (0.31) | GNAI3GNAO1GNAI1 | |
| SCHEMBL4695720 | 0.74 | SMN1; SMN2 (0.31) | GNAI3GNAO1GNAI1 | |
| SCHEMBL3861743 | 0.73 | — | — | |
| SCHEMBL27889783 | 0.71 | — | — | |
| SCHEMBL27969648 | 0.70 | — | — | |
| SCHEMBL23704748 | 0.70 | DPP4 (0.31) | — | |
| SCHEMBL6215052 | 0.70 | CYP1A2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013084241-A1 | COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2013-06-13 | — | — | WO | disclosed |
| EP-2421828-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF RENIN | Cadila Healthcare Limited (IN) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122580-A2 | NOVEL COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2010-10-28 | — | — | WO | disclosed |