Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10348908 | 0.91 | MEN1 (0.69) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL10349425 | 0.90 | KDM4E (0.73) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL16627028 | 0.88 | MEN1 (0.59) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL10799546 | 0.86 | KDM4E (0.69) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL13430578 | 0.86 | KDM4E (0.69) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL10223068 | 0.86 | KDM4E (0.69) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL21328333 | 0.86 | BCHE (0.72) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL10348903 | 0.84 | BCHE (0.56) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL10348796 | 0.83 | BCHE (0.58) | MEN1KMT2AKDM4EMAPTPKM | |
| SCHEMBL10348793 | 0.83 | BCHE (0.58) | MEN1KMT2AKDM4EMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322617-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024653-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-03-28 | — | — | WO | disclosed |