Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 7/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997903 | 0.84 | EGFR (0.64) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8315268 | 0.81 | EGFR (0.54) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6997055 | 0.80 | EGFR (0.65) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6986988 | 0.79 | EGFR (0.72) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8319823 | 0.78 | EGFR (0.64) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6994978 | 0.77 | EGFR (0.58) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6995224 | 0.76 | EGFR (0.56) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6996373 | 0.76 | EGFR (0.58) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6997746 | 0.75 | EGFR (0.61) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6993578 | 0.75 | EGFR (0.58) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |