⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2289867 | 0.76 | — | — | |
| SCHEMBL9110815 | 0.70 | — | — | |
| Medronic Acid SCHEMBL8350837 | 0.70 | KDM4E (1.00) | — | |
| SCHEMBL7334812 | 0.70 | — | — | |
| Medronic Acid SCHEMBL66716 | 0.70 | — | — | |
| SCHEMBL8352725 | 0.70 | TYMS (0.69) | — | |
| SCHEMBL215192 | 0.70 | — | — | |
| SCHEMBL81370 | 0.70 | TYMS (0.69) | — | |
| SCHEMBL3192524 | 0.67 | — | — | |
| SCHEMBL9793676 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369409-B1 | Carbocyclic nucleosides and nucleotides | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1995-01-04 | — | — | EP | claimed |
| EP-0369409-A1 | Carbocyclic nucleosides and nucleotides | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1990-05-23 | — | — | EP | claimed |
| CN-106795188-B | Nucleotide analogs | 加利福尼亚大学董事会 | 2021-02-09 | — | — | CN | disclosed |
| EP-3728283-A1 | 3'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) | 2020-10-28 | — | — | EP | disclosed |
| EP-3728282-A1 | 2'3' CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. (CZ) | 2020-10-28 | — | — | EP | disclosed |
| CN-111808136-A | Nucleotide analogs | 加利福尼亚大学董事会 | 2020-10-23 | — | — | CN | disclosed |
| CN-110156838-A | Phosphoric acid/phosphonate derivative and its medical usage | 北京美倍他药物研究有限公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-108383875-A | A kind of the 3- phosphonomethyls indoline and preparation method of silver catalysis | 昆明学院 | 2018-08-10 | — | — | CN | disclosed |
| CN-104072539-B | Double (4 acetaminophenol epoxide) esters of tenofovir and preparation method thereof and its application | 安徽贝克联合制药有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-102977146-B | A kind of synthetic method of adenine derivative | XINGHU BIOTECH CO., LTD., ZHAOQING CITY, GUANGDONG PROV. (CN) | 2016-04-20 | — | — | CN | disclosed |
| CN-103038241-B | Crystals of tenofovir disoproxil fumarate | JIANGSU CHIATAI TIANQING PHARMACEUTICAL CO LTD | 2015-06-17 | — | — | CN | disclosed |
| EP-0269947-B2 | Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1996-10-16 | — | — | EP | disclosed |
| US-5514798-A | REACTION OF CYCLIC CARBONATE WITH PURINE OR PYRIMIDINE BASE IN SOLVENT AND CRYSTALLIZATION | GILEAD SCIENCES, INC. (US) | 1996-05-07 | — | — | US | disclosed |
| EP-0452935-B1 | Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1995-06-21 | — | — | EP | disclosed |
| EP-0369409-B1 | Carbocyclic nucleosides and nucleotides | ACAD OF SCIENCE CZECH REPUBLIC (CS) | 1995-01-04 | — | — | EP | disclosed |
| EP-0205826-B1 | PHOSPHONYLMETHOXYALKYL ADENINES FOR THE TREATMENT OF VIRUS DISEASES | Stichting REGA V.Z.W. (BE) | 1992-03-18 | — | — | EP | disclosed |
| EP-0452935-A1 | Chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1991-10-23 | — | — | EP | disclosed |
| EP-0369409-A1 | Carbocyclic nucleosides and nucleotides | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CS) | 1990-05-23 | — | — | EP | disclosed |
| US-4724233-A | VIRICIDES | STICHTING REGA VZW (BE) | 1988-02-09 | — | — | US | disclosed |
| EP-0205826-A2 | Phosphonylmethoxyalkyl adenines for the treatment of virus diseases | Stichting REGA V.Z.W. (BE) | 1986-12-30 | — | — | EP | disclosed |