Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 17/20 | 0.75 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | FPR3 | P25089 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | GPR183 | P32249 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.57 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.57 |
| ▸ | P2RY13 | Q9BPV8 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997452 | 0.93 | P2RY12 (0.74) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL6997700 | 0.93 | P2RY12 (0.86) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL6995324 | 0.92 | P2RY12 (0.72) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL6997174 | 0.91 | P2RY12 (0.72) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL6999733 | 0.90 | P2RY12 (0.69) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL7000869 | 0.90 | P2RY12 (0.68) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL6990375 | 0.89 | P2RY12 (0.78) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL6999295 | 0.88 | P2RY12 (0.84) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL6994009 | 0.88 | P2RY12 (0.77) | P2RY12PGRADORA3CHRM1DRD1 | |
| SCHEMBL6998580 | 0.88 | P2RY12 (0.72) | P2RY12PGRADORA3CHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056749-B1 | NOVEL TRIAZOLO(4,5-d)PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2003-02-19 | — | — | EP | claimed |
| EP-1056749-B1 | NOVEL TRIAZOLO(4,5-d)PYRIMIDINE COMPOUNDS | ASTRAZENECA UK LTD (GB) | 2003-02-19 | — | — | EP | disclosed |
| US-6369064-B1 | MYOCARDIAL INFARCTION AND UNSTABLE ANGINA; P2T-RECEPTOR ANTAGONISTS; ANTITHROMBOTIC AGENTS; 7-(SUBSTITUTED AMINO) -5-(THIO)-3H-1,2,3-TRIAZOLO(4,5-D)PYRIMIDIN-3-YL) -CYCLOPENTANECARBOXAMIDES | ASTRAZENECA AB (SE) | 2002-04-09 | — | — | US | disclosed |