Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.54 |
| ▸ | JAK3 | P52333 | 8/20 | 0.53 |
| ▸ | JAK1 | P23458 | 4/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 5/20 | 0.50 |
| ▸ | CDK4 | P11802 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 3/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 2/20 | 0.50 |
| ▸ | CIT | O14578 | 2/20 | 0.50 |
| ▸ | GAK | O14976 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699825 | 0.86 | JAK2 (0.69) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL700072 | 0.83 | SYK (0.49) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL7981330 | 0.81 | CDK2 (0.55) | CDK2CDK4AURKACDK9CCNE1 | |
| SCHEMBL7977194 | 0.81 | CDK2 (0.55) | CDK2CDK4AURKACDK9CCNE1 | |
| SCHEMBL7975412 | 0.80 | CDK2 (0.54) | CDK2CDK4AURKAAURKBCDK9 | |
| SCHEMBL7977441 | 0.80 | CDK2 (0.54) | CDK2CDK4AURKACDK9CCNE1 | |
| SCHEMBL7976842 | 0.80 | CDK2 (0.54) | HDAC1CDK2CDK4AURKACDK9 | |
| SCHEMBL7978515 | 0.79 | CDK2 (0.60) | HDAC1CDK2CDK4AURKAAURKB | |
| SCHEMBL1684693 | 0.79 | CDK2 (0.80) | HDAC1CDK2CDK4AURKAAURKB | |
| SCHEMBL2865873 | 0.79 | JAK2 (0.82) | JAK2JAK3JAK1TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124764-B2 | Fused heterocyclyc inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2303881-A2 | FUSED HETEROCYCLYC INHIBITORS OF HISTONE DEACETYLASE AND/OR CYCLIN-DEPENDENT KINASES | GILEAD SCIENCES, INC. (US) | 2011-04-06 | — | — | EP | disclosed |
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2010-02-04 | — | — | US | disclosed |
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029638-A1 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | HDAC1, HDAC11, HDAC7 | JAK2 745/4885JAK3 1359/4885JAK1 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.