Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | BCL6 | P41182 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994986 | 0.89 | EGFR (0.73) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8315818 | 0.88 | EGFR (0.70) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL7001287 | 0.86 | EGFR (0.76) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8315823 | 0.86 | EGFR (0.71) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL7587164 | 0.86 | EGFR (0.67) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL7587170 | 0.86 | EGFR (0.67) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6995247 | 0.86 | EGFR (0.62) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL6993747 | 0.86 | EGFR (0.75) | EGFRERBB2HPGDHTTIRAK4 | |
| SCHEMBL8314263 | 0.84 | EGFR (0.84) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6990223 | 0.84 | EGFR (0.73) | EGFRERBB2HPGDHTTIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |