Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990936 | 1.00 | MDM2 (0.81) | MDM2CYP1A2CTNNB1ALPIPKM | |
| SCHEMBL7164412 | 1.00 | MDM2 (0.81) | MDM2CYP1A2CTNNB1ALPIPKM | |
| SCHEMBL11713368 | 0.90 | MDM2 (1.00) | MDM2CYP1A2CTNNB1ALPIPKM | |
| SCHEMBL7037701 | 0.88 | MDM2 (0.88) | MDM2CYP1A2CTNNB1ALPIPKM | |
| SCHEMBL3355858 | 0.88 | MDM2 (0.88) | MDM2CYP1A2CTNNB1ALPIPKM | |
| SCHEMBL7349956 | 0.86 | CYP1A2 (0.59) | MDM2CYP1A2ALPIPKMPTGS1 | |
| SCHEMBL9242408 | 0.83 | MDM2 (0.79) | MDM2CYP1A2CTNNB1ALPIPKM | |
| SCHEMBL6990924 | 0.83 | MDM2 (0.79) | MDM2CYP1A2CTNNB1ALPIPKM | |
| SCHEMBL2138695 | 0.83 | MDM2 (0.79) | MDM2CYP1A2CTNNB1ALPIPKM | |
| SCHEMBL7164409 | 0.83 | MDM2 (0.79) | MDM2CYP1A2CTNNB1ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641343-B1 | 4-MERCAPTOACETYLAMINO-[2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL PHARMA INC (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-0481522-B1 | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5527795-A | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-18 | — | — | US | disclosed |
| US-5491143-A | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5430145-A | Analgesics, reduction of drug withdrawal symptoms, hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0641343-A1 | 4-MERCAPTOACETYLAMINO- 2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023397-A1 | 4-MERCAPTOACETYLAMINO-[2] BENZAZEPINONE(3) DERIVATIVES, AND USE AS ENKEPHALINASE INHIBITORS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5238932-A | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0481522-A1 | Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1992-04-22 | — | — | EP | disclosed |