Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991661 | 0.89 | HRH3 (0.41) | HRH3SLC6A4HRH2HRH1KDM2B | |
| SCHEMBL7028310 | 0.89 | MCHR1 (0.43) | HRH3SLC6A4HTR1AMAPTMCHR1 | |
| SCHEMBL6738560 | 0.89 | HRH3 (0.42) | HRH3SLC6A4ARHRH2HRH1 | |
| SCHEMBL6996607 | 0.89 | HRH3 (0.43) | HRH3SLC6A4HRH2HRH1DRD3 | |
| SCHEMBL7030839 | 0.89 | HRH3 (0.41) | HRH3SLC6A4ARHRH2HRH1 | |
| SCHEMBL6740792 | 0.89 | SLC6A4 (0.41) | HRH3SLC6A4HRH2HRH1HTR1A | |
| SCHEMBL6993367 | 0.88 | HRH3 (0.40) | HRH3SLC6A4ARHRH2HRH1 | |
| SCHEMBL7034759 | 0.86 | SLC6A4 (0.39) | HRH3SLC6A4HRH2HRH1HTR1A | |
| SCHEMBL6995417 | 0.86 | SLC6A4 (0.39) | HRH3SLC6A4HRH2HRH1HTR1A | |
| SCHEMBL6997329 | 0.86 | SLC6A4 (0.39) | HRH3SLC6A4HRH2HRH1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301510-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002004446-A1 | NEW BISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-01-17 | — | — | WO | disclosed |