Sugi Predict

Sugi Predict / Compounds / SCHEMBL699128

SCHEMBL699128

SCHEMBL699128

O=C1Nc2ccccc2/C1=C\c1ccc(-c2cccc(C(=O)NCCN3CCCC3)c2)o1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PIM1 P11309 10/20 1.00
▸ PIM2 Q9P1W9 8/20 0.83
▸ PDPK1 O15530 2/20 0.55
▸ AKT2 P31751 2/20 0.55
▸ FLT3 P36888 2/20 0.52
▸ PIM3 Q86V86 1/20 0.52
▸ KMT2A Q03164 3/20 0.49
▸ MITF O75030 2/20 0.49
▸ GSK3A P49840 1/20 0.49
▸ GSK3B P49841 1/20 0.49
▸ CHEK1 O14757 2/20 0.49
▸ SMYD2 Q9NRG4 1/20 0.47
▸ ERN1 O75460 1/20 0.46
▸ POLB P06746 2/20 0.46
▸ MEN1 O00255 1/20 0.45
▸ GFER P55789 1/20 0.45
▸ CTDSP1 Q9GZU7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL699129 1.00 PIM1 (1.00) PIM1PIM2PDPK1AKT2FLT3
SCHEMBL10091743 0.91 PIM1 (0.83) PIM1PIM2PDPK1AKT2KMT2A
SCHEMBL10091434 0.91 PIM1 (0.83) PIM1PIM2PDPK1AKT2FLT3
SCHEMBL10091602 0.91 PIM1 (0.88) PIM1PIM2PDPK1AKT2FLT3
SCHEMBL10091543 0.91 PIM1 (1.00) PIM1PIM2PDPK1AKT2FLT3
SCHEMBL10091456 0.91 PIM1 (1.00) PIM1PIM2PDPK1AKT2FLT3
SCHEMBL10091570 0.90 PIM1 (0.81) PIM1PIM2PDPK1AKT2FLT3
SCHEMBL10091452 0.89 PIM1 (0.81) PIM1PIM2PDPK1AKT2FLT3
SCHEMBL10091778 0.89 PIM1 (0.79) PIM1PIM2PDPK1AKT2FLT3
SCHEMBL10091433 0.89 PIM1 (0.80) PIM1PIM2PDPK1AKT2FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120190669-A1 OXINDOLE COMPOUNDS CYLENE PHARMACEUTICALS, INC. (US) 2012-07-26 — — US disclosed
US-20120190669-A1 OXINDOLE COMPOUNDS CYLENE PHARMACEUTICALS, INC. (US) 2012-07-26 — — US disclosed
US-20120190669-A1 OXINDOLE COMPOUNDS CYLENE PHARMACEUTICALS, INC. (US) 2012-07-26 — — US disclosed
US-8124649-B2 Oxindole compounds CYLENE PHARMACEUTICALS, INC. (US) 2012-02-28 — — US disclosed
US-8124649-B2 Oxindole compounds CYLENE PHARMACEUTICALS, INC. (US) 2012-02-28 — — US disclosed
US-8124649-B2 Oxindole compounds CYLENE PHARMACEUTICALS, INC. (US) 2012-02-28 — — US disclosed
EP-2307421-A1 OXINDOLE COMPOUNDS Cylene Pharmaceuticals, Inc. (US) 2011-04-13 — — EP disclosed
US-20100041635-A1 OXINDOLE COMPOUNDS CYLENE PHARMACEUTICALS, INC. 2010-02-18 — — US disclosed
US-20100041635-A1 OXINDOLE COMPOUNDS CYLENE PHARMACEUTICALS, INC. 2010-02-18 — — US disclosed
US-20100041635-A1 OXINDOLE COMPOUNDS CYLENE PHARMACEUTICALS, INC. 2010-02-18 — — US disclosed
WO-2010002933-A1 OXINDOLE COMPOUNDS CYLENE PHARMACEUTICALS, INC. (US) 2010-01-07 — — WO disclosed
WO-2010002933-A1 OXINDOLE COMPOUNDS CYLENE PHARMACEUTICALS, INC. (US) 2010-01-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100041635-A1 OXINDOLE COMPOUNDS FLT3, PIM1, PIM2 PIM1 2/4885PIM2 3/4885PDPK1 113/4885
US-20120190669-A1 OXINDOLE COMPOUNDS FLT3, PIM1, PIM2 PIM1 2/4885PIM2 3/4885PDPK1 113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.