Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.51 |
| ▸ | SRC | P12931 | 6/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.51 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443449 | 0.90 | EGFR (0.56) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL4445551 | 0.87 | IGF1R (0.53) | EGFRERBB2SRCIGF1RMAP2K1 | |
| SCHEMBL4445445 | 0.85 | EGFR (0.61) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL4443460 | 0.84 | EGFR (0.71) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL4445590 | 0.84 | EGFR (0.61) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL4447122 | 0.83 | MAP2K1 (0.70) | EGFRERBB2SRCIGF1RMAP2K1 | |
| SCHEMBL2200378 | 0.83 | EGFR (0.66) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL2203629 | 0.83 | EGFR (0.66) | EGFRERBB2SRCMAP2K1 | |
| SCHEMBL4447786 | 0.82 | EGFR (0.59) | EGFRERBB2SRCIGF1RMAP2K1 | |
| SCHEMBL4450583 | 0.82 | MAP2K1 (0.75) | EGFRERBB2SRCIGF1RMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |