Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105539 | 0.95 | NPC1 (0.51) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL5098548 | 0.85 | NPC1 (0.52) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL5099007 | 0.81 | MAOB (0.56) | MAPK1MAOBHSP90AA1MAPTLMNA | |
| SCHEMBL7914606 | 0.80 | NPC1 (0.56) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL6700041 | 0.76 | ABCB1 (0.53) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL3927869 | 0.76 | NPC1 (0.52) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL10547115 | 0.76 | MAOB (0.62) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL6187602 | 0.76 | NR1H4 (0.64) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL9749067 | 0.75 | ABCB1 (0.57) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL13720748 | 0.75 | PPARA (0.62) | HPGDNPC1MAPK1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313715-A1 | OXAZOLYL-ARYLOXYACETIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | ELI LILLY AND COMPANY (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018355-A1 | OXAZOLYL-ARYLOXYACETIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-03-07 | — | — | WO | disclosed |