Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 4/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5620883 | 0.83 | MAOB (0.54) | MAOBMAOAALOX5BCHECYP4F2 | |
| SCHEMBL1826161 | 0.80 | MAOB (0.43) | MAOBKDM4E | |
| SCHEMBL8710346 | 0.79 | MAOB (0.69) | MAOBMAOABCHECYP4F2CYP4A11 | |
| SCHEMBL8674540 | 0.78 | MAOB (0.71) | MAOBMAOABCHECYP4F2CYP4A11 | |
| SCHEMBL13859154 | 0.76 | MAOB (0.64) | MAOBMAOAALOX5BCHECYP4F2 | |
| SCHEMBL1009475 | 0.76 | MAOB (0.68) | MAOBMAOAALOX5BCHECYP4F2 | |
| SCHEMBL1351689 | 0.75 | BCHE (0.64) | MAOBMAOAALOX5BCHECYP4F2 | |
| SCHEMBL6190936 | 0.75 | MAPT (0.44) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7489763 | 0.74 | MAOB (0.62) | MAOBMAOAALOX5BCHECYP4F2 | |
| SCHEMBL9434797 | 0.74 | BCHE (0.58) | MAOBMAOAALOX5BCHECYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322617-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024653-A1 | COMPOUNDS AND METHODS FOR MODULATION OF ESTROGEN RECEPTORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-03-28 | — | — | WO | disclosed |