Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.46 |
| ▸ | SRC | P12931 | 5/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454659 | 0.88 | SRC (0.55) | EGFRERBB2SRCIGF1RSTK4 | |
| SCHEMBL6382063 | 0.82 | EGFR (0.66) | EGFRERBB2SRCMAP3K8 | |
| SCHEMBL7001573 | 0.78 | EGFR (0.55) | EGFRERBB2SRCIGF1RSTK4 | |
| SCHEMBL7001957 | 0.77 | IGF1R (0.71) | EGFRERBB2IGF1RMAP2K1 | |
| SCHEMBL6384796 | 0.76 | EGFR (0.64) | EGFRERBB2 | |
| SCHEMBL6384002 | 0.75 | EGFR (0.52) | EGFRERBB2SRCMAP3K8MAP2K1 | |
| SCHEMBL6998072 | 0.74 | MAP2K1 (0.57) | EGFRERBB2SRCIGF1RMAP2K1 | |
| SCHEMBL6999196 | 0.73 | EGFR (0.59) | EGFRERBB2SRCSTK4MAP3K8 | |
| SCHEMBL6379771 | 0.72 | SRC (0.61) | EGFRERBB2SRCSTK4MAP3K8 | |
| SCHEMBL6383067 | 0.72 | EGFR (0.69) | EGFRERBB2SRCMAP3K8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |