Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.61 |
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.57 |
| ▸ | FBP1 | P09467 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7226666 | 0.92 | KDR (0.68) | EGFRKDREPHA2EPHB4FBP1 | |
| SCHEMBL7226668 | 0.92 | KDR (0.68) | EGFRKDREPHA2EPHB4FBP1 | |
| SCHEMBL6998297 | 0.88 | EGFR (0.70) | EGFRKDREPHA2EPHB4FBP1 | |
| SCHEMBL7221348 | 0.88 | EGFR (0.70) | EGFRKDREPHA2EPHB4FBP1 | |
| Hydrochloric Acid SCHEMBL6990351 | 0.87 | KDR (0.60) | EGFRKDREPHA2EPHB4FBP1 | |
| SCHEMBL6993684 | 0.83 | EGFR (0.63) | EGFRKDREPHA2EPHB4FBP1 | |
| SCHEMBL6989639 | 0.83 | EPHA2 (0.70) | EGFRKDREPHA2EPHB4FBP1 | |
| SCHEMBL7221051 | 0.83 | EPHA2 (0.70) | EGFRKDREPHA2EPHB4FBP1 | |
| SCHEMBL7219862 | 0.83 | EPHA2 (0.70) | EGFRKDREPHA2EPHB4FBP1 | |
| SCHEMBL7221058 | 0.83 | EPHA2 (0.70) | EGFRKDREPHA2EPHB4FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315705-A1 | BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM ZENTRALE GMBH (DE) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002018351-A1 | BICYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE, AND METHODS FOR THE PRODUCTION THEREOF | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-03-07 | — | — | WO | disclosed |