Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.82 |
| ▸ | BACE1 | P56817 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12402570 | 0.85 | BACE1 (0.82) | MAPTBACE1POLBGFERMEN1 | |
| SCHEMBL1788517 | 0.84 | BACE1 (1.00) | MAPTBACE1POLBGFERMEN1 | |
| SCHEMBL1792241 | 0.84 | MAPT (0.76) | MAPTPOLBGFERMEN1KMT2A | |
| SCHEMBL2184492 | 0.84 | MAPT (0.75) | MAPTPOLBGFERMEN1KMT2A | |
| SCHEMBL1789659 | 0.83 | TTR (0.76) | MAPTPOLBGFERMEN1KMT2A | |
| SCHEMBL3139309 | 0.82 | MAPT (0.85) | MAPTBACE1POLBGFERMEN1 | |
| SCHEMBL1790743 | 0.81 | MAPT (0.82) | MAPTBACE1POLBGFERMEN1 | |
| SCHEMBL190100 | 0.81 | MEN1 (0.80) | MAPTPOLBGFERMEN1KMT2A | |
| SCHEMBL1793147 | 0.81 | MAPT (0.76) | MAPTPOLBGFERMEN1KMT2A | |
| SCHEMBL15256408 | 0.81 | MAPT (0.73) | MAPTPOLBGFERMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065057-A2 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |