Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986984 | 0.89 | KMT2A (0.57) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL6986623 | 0.89 | KMT2A (0.44) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL6984524 | 0.87 | KMT2A (0.45) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL7139639 | 0.87 | KMT2A (0.48) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL6987768 | 0.85 | KMT2A (0.44) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL6989701 | 0.84 | KMT2A (0.41) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL6989621 | 0.83 | HPGD (0.44) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL6988649 | 0.82 | PSEN1 (0.42) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL6991652 | 0.81 | KMT2A (0.45) | KMT2AALDH1A1HTTGAAHPGD | |
| SCHEMBL6275082 | 0.81 | KMT2A (0.42) | KMT2AALDH1A1HTTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341779-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2003-09-10 | — | — | EP | claimed |
| WO-2002057252-A2 | HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2002-07-25 | — | — | WO | claimed |