Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | C1R | P00736 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370167 | 0.87 | ELANE (0.68) | ELANEMEN1KMT2AC1R | |
| SCHEMBL6342514 | 0.84 | ELANE (0.64) | ELANEMEN1KMT2AC1R | |
| SCHEMBL6136297 | 0.82 | ELANE (0.83) | ELANEMEN1KMT2AC1RPDE10A | |
| SCHEMBL692733 | 0.82 | ELANE (0.81) | ELANEMEN1KMT2AC1RPDE10A | |
| SCHEMBL29405904 | 0.82 | ELANE (0.81) | ELANEMEN1KMT2AC1RPDE10A | |
| SCHEMBL10340248 | 0.81 | ELANE (0.59) | ELANEMEN1KMT2AC1RPDE10A | |
| SCHEMBL14068580 | 0.81 | ELANE (0.64) | ELANEMEN1KMT2A | |
| SCHEMBL692829 | 0.79 | ELANE (0.76) | ELANEMEN1KMT2AC1RPDE10A | |
| SCHEMBL3112570 | 0.79 | NPC1 (0.61) | MEN1KMT2ANR4A1NR4A2NR4A3 | |
| SCHEMBL31614347 | 0.79 | NPC1 (0.61) | MEN1KMT2ANR4A1NR4A2NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-B1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PFIZER HOLDING FRANCE (FR) | 2003-02-12 | — | — | EP | disclosed |
| US-6239130-B1 | ASTHMA, ATOPIC DERMATITIS, RHEUMATOID ARTHRITIS, INFLAMMATORY BOWEL DISORDERS, PULMONARY HYPERTENSION, LIVER INJURY, BONE LOSS, SEPTIC SHOCK, OR MULTIPLE SCLEROSIS, | WARNER-LAMBERT COMPANY | 2001-05-29 | — | — | US | disclosed |
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | disclosed |