Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 10/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 10/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992940 | 1.00 | TACR1 (0.49) | TACR1GPBAR1 | |
| SCHEMBL6983798 | 0.92 | TACR1 (0.57) | TACR1GPBAR1 | |
| SCHEMBL6983809 | 0.92 | TACR1 (0.57) | TACR1GPBAR1 | |
| SCHEMBL6988800 | 0.92 | TACR1 (0.57) | TACR1GPBAR1 | |
| SCHEMBL6986187 | 0.87 | TACR1 (0.52) | TACR1GPBAR1 | |
| SCHEMBL6986957 | 0.85 | CNR1 (0.40) | TACR1 | |
| SCHEMBL6986953 | 0.85 | CNR1 (0.40) | TACR1 | |
| SCHEMBL6989508 | 0.79 | GPBAR1 (0.47) | TACR1GPBAR1 | |
| SCHEMBL6988712 | 0.79 | GPBAR1 (0.47) | TACR1GPBAR1 | |
| SCHEMBL6988719 | 0.79 | GPBAR1 (0.47) | TACR1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733632-B1 | Cyclic compounds, their production and use as tachykinin receptor antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-06-04 | — | — | EP | disclosed |
| US-6489315-B1 | NOVEL CYCLIC COMPOUNDS HAVING AN EXCELLENT TACHYKININ RECEPTOR ANTAGONISTIC EFFECT, AND A METHOD FOR PRODUCING THEM, FOR TREATING DISORDERS OF INCONTINENCE, ASTHMA, MIGRAINE, IRRITABLE BOWEL SYNDROME, PAIN, COUGH OR EMESIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-12-03 | — | — | US | disclosed |
| CN-1291099-A | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-04-11 | — | — | CN | disclosed |
| US-6147071-A | TACHYKININ RECEPTOR ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0733632-A1 | Cyclic compounds, their production and use as tachykinin receptor antagonists | Takeda Chemical Industries, Ltd. (JP) | 1996-09-25 | — | — | EP | disclosed |