Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409884 | 0.93 | EGFR (0.62) | EGFRMKNK2KDM4EMAPK1 | |
| SCHEMBL6996289 | 0.87 | KDR (0.53) | EGFRMKNK2LMNANPC1MAPT | |
| SCHEMBL6993198 | 0.87 | EGFR (0.54) | EGFRMKNK2 | |
| SCHEMBL26696575 | 0.84 | EGFR (0.48) | EGFRMKNK2CYP1A2CYP3A4 | |
| SCHEMBL6996950 | 0.84 | EGFR (0.56) | EGFRMKNK2MEN1NPC1MAPT | |
| SCHEMBL6996349 | 0.80 | EGFR (0.48) | EGFRLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6997797 | 0.80 | EGFR (0.67) | EGFRMAPK1HIF1A | |
| SCHEMBL6999229 | 0.80 | EGFR (0.45) | EGFRMAPTHPGD | |
| SCHEMBL8487486 | 0.79 | EGFR (0.42) | EGFRMEN1NPC1MAPTHPGD | |
| SCHEMBL6997920 | 0.78 | EGFR (0.56) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |