Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSK | P41240 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537418 | 0.87 | FLT3 (0.44) | CSKBTKERBB4CAMK1GFLT3 | |
| SCHEMBL3537420 | 0.87 | FLT3 (0.44) | CSKBTKERBB4CAMK1GFLT3 | |
| SCHEMBL3538983 | 0.85 | FLT3 (0.54) | FLT3 | |
| SCHEMBL3538985 | 0.85 | FLT3 (0.54) | FLT3 | |
| SCHEMBL3537697 | 0.81 | FLT3 (0.41) | FLT3 | |
| SCHEMBL3537700 | 0.81 | FLT3 (0.41) | FLT3 | |
| SCHEMBL3544717 | 0.80 | FLT3 (0.45) | FLT3 | |
| SCHEMBL3544714 | 0.80 | FLT3 (0.45) | FLT3 | |
| SCHEMBL3541297 | 0.80 | FLT3 (0.40) | FLT3MEN1KMT2A | |
| SCHEMBL3541295 | 0.80 | FLT3 (0.40) | FLT3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318985-A2 | 4-AMINO-QUINAZOLINES | MERCK PATENT GmbH (DE) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024666-A2 | 4-AMINO-QUINAZOLINES | MERCK PATENT GMBH (DE) | 2002-03-28 | — | — | WO | disclosed |