Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | BCL6 | P41182 | 1/20 | 0.55 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | FBP1 | P09467 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | TEK | Q02763 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314039 | 0.90 | EGFR (0.52) | EGFRERBB2HPGDHTTBCL6 | |
| SCHEMBL8314431 | 0.89 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6990991 | 0.89 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8316049 | 0.89 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6990908 | 0.88 | EGFR (0.58) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8315885 | 0.87 | EGFR (0.57) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6999556 | 0.87 | EGFR (0.57) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL6999525 | 0.87 | EGFR (0.57) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8319458 | 0.87 | EGFR (0.59) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8313815 | 0.86 | EGFR (0.58) | EGFRERBB2HPGDHTTGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |