Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994853 | 1.00 | F2 (0.40) | F2PRSS1PRSS2PRSS3KMT2A | |
| Hydrochloric Acid SCHEMBL7992387 | 0.99 | F2 (0.39) | F2PRSS1PRSS2PRSS3KMT2A | |
| Hydrochloric Acid SCHEMBL7992547 | 0.99 | F2 (0.39) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL7000162 | 0.90 | KMT2A (0.43) | F2PRSS1PRSS2PRSS3KMT2A | |
| Hydrochloric Acid SCHEMBL7989044 | 0.90 | KMT2A (0.42) | F2PRSS1PRSS2PRSS3KMT2A | |
| SCHEMBL7301539 | 0.85 | F2 (0.37) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7292153 | 0.85 | F2 (0.37) | F2PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL7992549 | 0.85 | F2 (0.36) | F2PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL7992390 | 0.85 | F2 (0.36) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6992396 | 0.81 | F2 (0.48) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |