Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996377 | 0.84 | EGFR (0.62) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6986993 | 0.84 | EGFR (0.76) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6989080 | 0.81 | EGFR (0.72) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6994978 | 0.81 | EGFR (0.58) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6997903 | 0.81 | EGFR (0.64) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8316693 | 0.80 | EGFR (0.59) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6997355 | 0.80 | EGFR (0.61) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL4351961 | 0.80 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6990926 | 0.80 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6996566 | 0.80 | EGFR (0.60) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |