Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | USP10 | Q14694 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996040 | 1.00 | SERPINE1 (0.39) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL6996037 | 1.00 | SERPINE1 (0.39) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL6998667 | 0.85 | SERPINE1 (0.39) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL6998671 | 0.85 | SERPINE1 (0.39) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL6989772 | 0.84 | HDAC3 (0.41) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL6989769 | 0.84 | HDAC3 (0.41) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL6992685 | 0.84 | HDAC3 (0.41) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL8689908 | 0.83 | HDAC3 (0.40) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL8685226 | 0.83 | HDAC3 (0.40) | SERPINE1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL8685235 | 0.83 | HDAC3 (0.40) | SERPINE1SYKHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846111-B1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-5981748-A | Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates | AGOURON PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5831100-A | Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-03 | — | — | US | disclosed |