Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 13/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17501926 | 0.83 | PTGER2 (0.44) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL16096237 | 0.83 | PTGER2 (0.44) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL18013330 | 0.81 | HDAC1 (0.44) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL16422722 | 0.81 | HDAC1 (0.49) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL16423061 | 0.81 | HDAC1 (0.49) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL16422721 | 0.81 | HDAC1 (0.49) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL12487339 | 0.80 | CNR2 (0.45) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL12407036 | 0.78 | HDAC6 (0.42) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL12407034 | 0.77 | HDAC1 (0.42) | HDAC1HDAC8HDAC6PTGER2PTGER3 | |
| SCHEMBL10065847 | 0.77 | PTGER2 (0.64) | HDAC1HDAC8HDAC6PTGER2PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345909-A1 | PHENYLACETAMIDO-PYRAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002048114-A1 | PHENYLACETAMIDO- PYRAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2002-06-20 | — | — | WO | disclosed |