Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K8 | P41279 | 5/20 | 0.47 |
| ▸ | EGFR | P00533 | 9/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.46 |
| ▸ | STK4 | Q13043 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001084 | 0.90 | MAP3K8 (0.48) | MAP3K8EGFRERBB2STK4SRC | |
| SCHEMBL6992365 | 0.90 | STK4 (0.49) | MAP3K8EGFRERBB2STK4SRC | |
| SCHEMBL4450592 | 0.89 | EGFR (0.53) | MAP3K8EGFRERBB2STK4SRC | |
| SCHEMBL4451215 | 0.83 | EGFR (0.55) | EGFRERBB2STK4SRC | |
| SCHEMBL6999196 | 0.83 | EGFR (0.59) | MAP3K8EGFRERBB2STK4SRC | |
| SCHEMBL4445586 | 0.82 | STK4 (0.63) | EGFRERBB2STK4SRC | |
| SCHEMBL7001712 | 0.81 | MAP2K1 (0.54) | MAP3K8EGFRERBB2SRC | |
| SCHEMBL4451048 | 0.77 | EGFR (0.78) | EGFRERBB2STK4SRCEIF2AK2 | |
| SCHEMBL4451042 | 0.77 | EGFR (0.78) | EGFRERBB2STK4SRCEIF2AK2 | |
| SCHEMBL4448963 | 0.77 | MAP2K1 (0.70) | EGFRERBB2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |