Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.52 |
| ▸ | PDE6C | P51160 | 3/20 | 0.51 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE6D | O43924 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | PDE9A | O76083 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PDE6A | P16499 | 1/20 | 0.48 |
| ▸ | PDE6G | P18545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001931 | 0.88 | PDE5A (0.54) | PDE5APDE6CPDE4APDE4BPDE4C | |
| SCHEMBL6338375 | 0.84 | PDE5A (0.68) | PDE5APDE6CPDE4APDE4BPDE4C | |
| SCHEMBL6331957 | 0.84 | PDE5A (0.64) | PDE5APDE6CPDE4APDE4BPDE4C | |
| SCHEMBL6999053 | 0.83 | PDE5A (0.79) | PDE5APDE6C | |
| SCHEMBL6334010 | 0.80 | PDE5A (0.57) | PDE5APDE6CPDE4APDE4BPDE4C | |
| SCHEMBL6336939 | 0.80 | PDE5A (0.58) | PDE5APDE6CPDE4APDE4BPDE4C | |
| SCHEMBL7030569 | 0.79 | PDE5A (0.59) | PDE5APDE6CPDE4APDE4BPDE4C | |
| SCHEMBL6332294 | 0.78 | PDE5A (0.52) | PDE5APDE6CPDE4APDE4BPDE4C | |
| SCHEMBL6330315 | 0.78 | PDE5A (0.54) | PDE5APDE6CPDE4APDE4BPDE4C | |
| SCHEMBL6339903 | 0.78 | PDE5A (0.58) | PDE5APDE6CKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |