Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197426 | 0.91 | PDE5A (0.81) | PDE5AKMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL6444664 | 0.90 | PDE5A (0.74) | PDE5AKMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL6999379 | 0.90 | PDE5A (0.69) | PDE5AKMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL7003001 | 0.87 | PDE5A (0.66) | PDE5AKMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL6856004 | 0.86 | PDE5A (0.67) | PDE5AKMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL6447569 | 0.86 | PDE5A (0.78) | PDE5AKMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL3586124 | 0.85 | PDE5A (0.74) | PDE5AKMT2A | |
| SCHEMBL6448057 | 0.85 | PDE5A (0.67) | PDE5AKMT2AALDH1A1KDM4ERXFP1 | |
| SCHEMBL2404751 | 0.84 | PDE5A (0.75) | PDE5AKMT2A | |
| SCHEMBL3573368 | 0.84 | PDE5A (0.88) | PDE5AKMT2AKDM4ERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-B1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LTD (GB) | 2003-09-17 | — | — | EP | disclosed |
| US-6333330-B1 | Pyrazolopyrimidinone CGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. | 2001-12-25 | — | — | US | disclosed |
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |