Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 17/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316275 | 0.90 | EGFR (0.75) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8487889 | 0.87 | EGFR (0.70) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6992486 | 0.87 | EGFR (0.69) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8317849 | 0.86 | EGFR (0.71) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6998310 | 0.85 | EGFR (0.69) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL7585703 | 0.85 | EGFR (0.69) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6995085 | 0.85 | EGFR (0.73) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL7582446 | 0.84 | EGFR (0.68) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6990205 | 0.84 | EGFR (0.74) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6989673 | 0.84 | EGFR (0.74) | EGFRERBB2MAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-B1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | THOMAE GMBH DR K (DE) | 2003-10-15 | — | — | EP | disclosed |