SCHEMBL6997058

SCHEMBL6997058

c1cncc2nccc-2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 9/20 0.57
ALDH1A1 P00352 3/20 0.56
CYP3A4 P08684 3/20 0.56
CYP1A2 P05177 1/20 0.56
LOXL2 Q9Y4K0 1/20 0.50
HSP90AA1 P07900 1/20 0.50
HSP90AB1 P08238 1/20 0.50
PTK2 Q05397 1/20 0.50
KDM4E B2RXH2 2/20 0.48
LMNA P02545 1/20 0.48
TP53 P04637 1/20 0.48
MAPT P10636 1/20 0.48
HPGD P15428 1/20 0.48
ALOX15 P16050 1/20 0.48
HTT P42858 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
HSD17B10 Q99714 1/20 0.48
RAB9A P51151 1/20 0.47
CYP11B1 P15538 2/20 0.46
CYP11B2 P19099 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28165095 1.00 CYP2A6 (0.57) CYP2A6ALDH1A1CYP3A4CYP1A2LOXL2
SCHEMBL4672073 0.84 CYP2A6 (0.67) CYP2A6ALDH1A1CYP3A4CYP1A2LOXL2
SCHEMBL31140239 0.84 CYP2A6 (0.67) CYP2A6ALDH1A1CYP3A4CYP1A2LOXL2
SCHEMBL6622238 0.81 CYP2A6 (0.76) CYP2A6ALDH1A1CYP3A4CYP1A2LOXL2
SCHEMBL29904375 0.81 CYP2A6 (0.52) CYP2A6ALDH1A1CYP3A4CYP1A2KDM4E
SCHEMBL166615 0.81 CYP2A6 (0.52) CYP2A6ALDH1A1CYP3A4CYP1A2KDM4E
Pyridine SCHEMBL28875197 0.80 CYP2A6 (0.57) CYP2A6ALDH1A1CYP3A4CYP1A2KDM4E
Hydrochloric Acid SCHEMBL6061020 0.79 CYP2A6 (0.50) CYP2A6ALDH1A1CYP3A4CYP1A2KDM4E
Hydrochloric Acid SCHEMBL4552312 0.79 CYP2A6 (0.50) CYP2A6ALDH1A1CYP3A4CYP1A2KDM4E
Ammonia Solution, Strong SCHEMBL27498840 0.79 CYP2A6 (0.50) CYP2A6ALDH1A1CYP3A4CYP1A2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110035759-A Maintenance of immune response during chemotherapeutic regimens G1治疗公司 2019-07-19 CN disclosed
CN-109415382-A Corticostatin analogs 哈佛学院院长等 2019-03-01 CN disclosed
CN-104193750-B Suppress mitotic Compounds and methods for by suppressing aurora kinase 千禧药品公司 2018-04-27 CN disclosed
CN-102863441-A Clic central nervous system active agents ABBOTT LAB 2013-01-09 CN disclosed
CN-100355755-C Diazabicyclic central nervous system active agents ABBOTT LAB (US) 2007-12-19 CN disclosed
EP-0915881-B1 PYRROLOAZEPINE COMPOUNDS SUNTORY LTD (JP) 2003-01-08 EP disclosed
EP-0711773-B1 HYMENIALDISINE AND DERIVATIVE THEREOF, PROCESS FOR PRODUCING INTERMEDIATE FOR SYNTHESIZING THE SAME, AND SAID INTERMEDIATE SUNTORY LTD (JP) 2001-09-12 EP disclosed
US-5621099-A CARDIOVASCULAR DISORDERS SUNTORY LIMITED (JP) 1997-04-15 US disclosed
EP-0711773-A1 HYMENIALDISINE AND DERIVATIVE THEREOF, PROCESS FOR PRODUCING INTERMEDIATE FOR SYNTHESIZING THE SAME, AND SAID INTERMEDIATE SUNTORY LIMITED (JP) 1996-05-15 EP disclosed